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KMID : 0370220160600040180
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Yakhak Hoeji
2016 Volume.60 No. 4 p.180 ~ p.186
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Probe-Sonicator Calibration for In Vitro Toxicological Testing of Nanoparticles
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Park Ju-Young
Lee han-Dule
Park Kwang-Sik
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Abstract
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NANoREG is a program for a common European approach to the regulatory testing of manufactured nanomaterials. NANoREG has an objective to provide answers and solutions to the questions and requirements from regulatory authorities. For this, NANoREG is generating physicochemical and toxicological data by interdisciplinary approaches and we have joined the program since January, 2015. According to the NANoREG program, it is necessary to fulfil the requirement of nanomaterial dispersion protocol before starting toxicity tests. So, we performed probe-sonicator calibration of delivered acoustic power based on the protocols provided by NANoREG. As results, the amplitude and time for sonication was obtained for the proper size distribution of standard nanomaterial, silica nanoparticles NM 200. All data we obtained belonged to the effective level and quality of the dispersion, 210 nm
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KEYWORD
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NANoREG, sonication calibration, nanomaterials, size distribution
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